Based on SPRI technology, in the magnetic bead method reaction system, nucleic acid molecules (DNA & RNA) will be compressed from linear to spherical shape. Benefiting from the development of high-throughput sequencing technology, magnetic beads are also highly regarded for their high throughput and applicability to automation. In addition, magnetic beads are widely used for DNA purification and double-round size selection (fragment screening) in next-generation sequencing (NGS) library preparation.

SPRI (Solid Phase Reverse Immobilization) is that paramagnetic beads can selectively bind to nucleic acids by type and size, and can be used to isolate, purify and clean up high purity nucleic acids. This technology can be applied to next generation sequencing (NGS), Sanger sequencing, qPCR, ddPCR and microarrays, etc.

The extraction of nucleic acid using magnetic beads is still a relatively new nucleic acid extraction method, compared with the traditional chloroform isoamyl alcohol extraction method and spin column kit method. This method is still not understood well by many people, and there are some misundersta