Based on SPRI technology, in the magnetic bead method reaction system, nucleic acid molecules (DNA & RNA) will be compressed from linear to spherical shape. Benefiting from the development of high-throughput sequencing technology, magnetic beads are also highly regarded for their high throughput and applicability to automation. In addition, magnetic beads are widely used for DNA purification and double-round size selection (fragment screening) in next-generation sequencing (NGS) library preparation.